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KMID : 0191120140290050743
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Journal of Korean Medical Science
2014 Volume.29 No. 5 p.743 ~ p.747
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Methylenetetrahydrofolate Reductase 677 Genotype-Specific Reference Values for Plasma Homocysteine and Serum Folate Concentrations in Korean Population Aged 45 to 74 Years: The Namwon Study
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Kweon Sun-Seog
Lee Young-Hoon
Jeong Seul-Ki
Nam Hae-Sung
Park Kyeong-Soo
Choi Seong-Woo
Kim Bok-Hee
Kim Hee-Nam
Choi Jin-Su
Shin Min-Ho
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Abstract
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The reference interval for plasma total homocysteine (tHcy) and serum folate concentrations were estimated. Total of 3,154 reference individuals (1,029 men and 2,125 women) were selected based on stringent exclusion criteria. For plasma tHcy concentration (μM/L), reference values (median [5-95 percentile]) were 7.72 (5.03 to 13.80) and 6.09 (3.95-10.19) in men and women, respectively. For serum folate concentration (nM/L), reference values were 23.71 (11.73-38.44) and 28.95 (15.23-40.44) in men and women, respectively. The tHcy levels of both genders in the present study were lower than those in previous reports from other countries and Korea.
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KEYWORD
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Homocysteine, Folic Acid, Reference Intervals, Aged Population
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